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Descriptor English:   DNA Topoisomerases, Type II 
Descriptor Spanish:   ADN-Topoisomerasas de Tipo II 
Descriptor Portuguese:   DNA Topoisomerases Tipo II 
Synonyms English:   DNA Topoisomerase (ATP-Hydrolysing)
DNA Topoisomerase II
DNA Topoisomerase II alpha
DNA Topoisomerase II beta
DNA Type 2 Topoisomerase
TOP2A Protein
TOP2B Protein
Topoisomerase II
Topoisomerase II alpha
Topoisomerase II beta
Type II DNA Topoisomerase
alpha, Topoisomerase II
beta, Topoisomerase II  
Tree Number:   D08.811.399.403.741
Definition English:   DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex. 
Entry Combination - descr/qualif English:   DNA Topoisomerases, Type II/antagonists & inhibitors use Topoisomerase II Inhibitors
History Note English:   2018(2002); use DNA GYRASE 1980-1993 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   31731 
Unique Identifier:   D004250 

Occurrence in VHL: