Search on: DEOXYRIBONUCLEASES, TYPE I SITE-SPECIFIC 
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Descriptor English:   Deoxyribonucleases, Type I Site-Specific 
Descriptor Spanish:   Desoxirribonucleasas de Localización Especificada Tipo I 
Descriptor Portuguese:   Desoxirribonucleases de Sítio Específico do Tipo I 
Synonyms English:   DNA Restriction Enzymes, Type I
DNase, Site Specific, Type I
DNase, Site-Specific, Type I
Deoxyribonucleases, Type I Site Specific
Deoxyribonucleases, Type I, Site Specific
Deoxyribonucleases, Type I, Site-Specific
Restriction Endonucleases, Type I
Site Specific DNase, Type I
Site-Specific DNase, Type I
Type I Restriction Enzymes
Type I Site Specific DNase
Type I Site Specific Deoxyribonucleases
Type I Site-Specific DNase
Type I Site-Specific Deoxyribonucleases  
Tree Number:   D08.811.150.280.250
D08.811.277.352.335.350.300.250
D08.811.277.352.355.325.300.250
Definition English:   Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3. 
History Note English:   89 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   23602 
Unique Identifier:   D015253 

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