Search on: DIDANOSINE 
Descriptors Found: 1
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Descriptor English:   Didanosine 
Descriptor Spanish:   Didanosina 
Descriptor Portuguese:   Didanosina 
Synonyms English:   2',3' Dideoxyinosine
2',3'-Dideoxyinosine
Dideoxyinosine
NSC 612049
NSC-612049
NSC612049
Videx
ddI (Antiviral)  
Tree Number:   D03.633.100.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130
Definition English:   A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. 
Pharmacological Action:   Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
 
History Note English:   92; was DIDEOXYINOSINE 1990-91 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   30328 
Unique Identifier:   D016049 

Occurrence in VHL:
 
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DeCS