Search on: DIDEOXYNUCLEOSIDES 
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Descriptor English:   Dideoxynucleosides 
Descriptor Spanish:   Didesoxinucleósidos 
Descriptor Portuguese:   Didesoxinucleosídeos 
Synonyms English:   2',3' Dideoxynucleosides
2',3'-Dideoxynucleosides
Dideoxyribonucleosides
ddNus  
Tree Number:   D13.570.230.500
Definition English:   Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription. 
Indexing Annotation English:   antivirals & antimetabolites
Pharmacological Action:   Antimetabolites
Antiviral Agents
Reverse Transcriptase Inhibitors
 
History Note English:   89 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   23607 
Unique Identifier:   D015224 

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