Search on: DIPHOSPHONATES 
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Descriptor English:   Diphosphonates 
Descriptor Spanish:   Difosfonatos 
Descriptor Portuguese:   Difosfonatos 
Synonyms English:   Bisphosphonates  
Tree Number:   D02.705.429.500
Definition English:   Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents. 
Pharmacological Action:   Bone Density Conservation Agents
 
History Note English:   77 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   4220 
Unique Identifier:   D004164 

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