| Descriptor English: | Epidermal Growth Factor | ||||||
| Descriptor Spanish: |
Factor de Crecimiento Epidérmico
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| Descriptor Portuguese: | Fator de Crescimento Epidérmico | ||||||
| Descriptor French: | Facteur de croissance épidermique | ||||||
| Entry term(s): |
EGF Epidermal Growth Factor-Urogastrone Growth Factor, Epidermal Growth Factor-Urogastrone, Epidermal Human Urinary Gastric Inhibitor Urogastrone beta Urogastrone beta-Urogastrone |
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| Tree number(s): |
D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D004815 | ||||||
| Scope note: | A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Registry Number: | 62229-50-9 | ||||||
| CAS Type 1 Name: | Epidermal growth factor | ||||||
| Previous Indexing: |
Gastrointestinal Hormones (1966-1974) Growth Substances (1966-1976) Peptides (1966-1976) |
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| Public MeSH Note: | 2000; see EPIDERMAL GROWTH FACTOR-UROGASTRONE 1982-1999, see PEPTIDES 1977-1981; for UROGASTRONE see GASTROINTESTINAL HORMONES 1963-1981 |
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| History Note: | 2000(1982); use PEPTIDES 1977-1981; for UROGASTRONE use GASTROINTESTINAL HORMONES 1963-1981 |
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| Related: |
Anti-Ulcer Agents
MeSH ErbB Receptors MeSH Gastrointestinal Agents MeSH | ||||||
| DeCS ID: | 4896 | ||||||
| Unique ID: | D004815 | ||||||
| NLM Classification: | WK 170 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1982/01/01 | ||||||
| Date of Entry: | 1976/04/16 | ||||||
| Revision Date: | 2018/07/02 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Epidermal Growth Factor
- Preferred
| Concept UI |
M0007549 |
| Scope note | A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. |
| Preferred term | Epidermal Growth Factor |
| Entry term(s) |
EGF Epidermal Growth Factor-Urogastrone Growth Factor, Epidermal Growth Factor-Urogastrone, Epidermal Human Urinary Gastric Inhibitor Urogastrone beta Urogastrone beta-Urogastrone |
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