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Descriptor English: Echinocandins
Descriptor Spanish: Equinocandinas
Descriptor equinocandinas
Entry term(s) aculeacina
equinocandina
neumocandina
Scope note: Hexapéptidos cíclicos de prolina-ornitina-treonina-prolina-treonina-serina. La ciclización con una sola unión no peptídica puede llevar a que de modo incorrecto sean denominados DEPSIPÉPTIDOS, pero las equinocandinas carecen de las uniones éster. Su actividad antifúngica se efectúa por inhibición de la 1,3-beta-glucano sintasa en la producción de BETA GLUCANOS.
Descriptor Portuguese: Equinocandinas
Descriptor French: Échinocandines
Entry term(s): Aculeacin
Aculeacins
Echinocandin
Mulundocandins
Pneumocandin
Pneumocandins
Tree number(s): D12.644.641.311
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054714
Scope note: Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antifungal Agents
Previous Indexing: Peptides, Cyclic (1981-2007)
Public MeSH Note: 2008
History Note: 2008
DeCS ID: 52786
Unique ID: D054714
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2020/05/27
Echinocandins - Preferred
Concept UI M0507131
Scope note Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Preferred term Echinocandins
Entry term(s) Echinocandin
Mulundocandins - Narrower
Concept UI M0507196
Preferred term Mulundocandins
Aculeacins - Narrower
Concept UI M0507195
Preferred term Aculeacins
Entry term(s) Aculeacin
Pneumocandins - Narrower
Concept UI M0507194
Preferred term Pneumocandins
Entry term(s) Pneumocandin



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