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Descriptor English:   Estrogenic Steroids, Alkylated 
Descriptor Spanish:   Esteroides Estrogénicos Alquilados 
Descriptor Portuguese:   Esteroides Estrogênicos Alquilados 
Synonyms English:   Alkyl Estrogenic Steroids
Alkylated Estrogenic Steroids  
Tree Number:   D06.472.334.851.437.968
Definition English:   Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties. 
Pharmacological Action:   Estrogens
History Note English:   2004 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   38106 
Unique Identifier:   D042782 

Occurrence in VHL: