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Descriptor English: Floxuridine
Descriptor Spanish: Floxuridina
Descriptor floxuridina
Entry term(s) FUdR
fluorodesoxiuridina
Scope note: Antimetabolito antineoplásico que se metaboliza a fluorouracilo cuando se administra por inyección rápida; cuando se administra en infusión lenta, contínua e intra-arterial es convertido a monofosfato de floxuridina. Se ha usado para tratar las metástasis hepáticas de los adenocarcinomas gastrointestinales y como tratamiento paliativo de las neoplasias malignas del hígado y del tracto gastrointestinal.
Descriptor Portuguese: Floxuridina
Descriptor French: Floxuridine
Entry term(s): 5 Fluorodeoxyuridine
5-FUdR
5-Fluorodeoxyuridine
FUdR
Fluorodeoxyuridine
Tree number(s): D03.383.742.680.852.300.350
D13.570.230.430.432
D13.570.685.852.300.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005467
Scope note: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Annotation: an antiviral & antineoplastic antimetabolite
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimetabolites, Antineoplastic
Registry Number: 039LU44I5M
CAS Type 1 Name: Uridine, 2'-deoxy-5-fluoro-
Public MeSH Note: 93; was FLUORODEOXYURIDINE 1963-92; FLOXURIDINE was see FLUORODEOXYURIDINE 1976-92
Online Note: use FLOXURIDINE to search FLUORODEOXYURIDINE 1966-92
History Note: 93; was FLUORODEOXYURIDINE 1963-92; FLOXURIDINE was see FLUORODEOXYURIDINE 1976-92
DeCS ID: 30926
Unique ID: D005467
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Floxuridine - Preferred
Concept UI M0008626
Scope note An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Preferred term Floxuridine
Entry term(s) 5 Fluorodeoxyuridine
5-FUdR
5-Fluorodeoxyuridine
FUdR
Fluorodeoxyuridine



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