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Descriptor English: Geminin
Descriptor Spanish: Geminina
Descriptor geminina
Scope note: La geminina inhibe la duplicación del ADN impidiendo la incorporación del complejo MCM en el complejo prerreplicación. Está ausente durante la fase G1 del CICLO CELULAR y se acumula durante las fases S, G2 y M. Es degradada en la transición metafase-anafase por el COMPLEJO PROMOTOR DE LA ANAFASE-CICLOSOMA.
Descriptor Portuguese: Geminina
Descriptor French: Géminine
Tree number(s): D12.776.167.265
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064248
Scope note: Geminin inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex. It is absent during G1 phase of the CELL CYCLE and accumulates through S, G2,and M phases. It is degraded at the metaphase-anaphase transition by the ANAPHASE-PROMOTING COMPLEX-CYCLOSOME.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Cell Cycle Proteins (1998-2013)
History Note: 2014
DeCS ID: 55326
Unique ID: D064248
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Geminin - Preferred
Concept UI M0580547
Scope note Geminin inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex. It is absent during G1 phase of the CELL CYCLE and accumulates through S, G2,and M phases. It is degraded at the metaphase-anaphase transition by the ANAPHASE-PROMOTING COMPLEX-CYCLOSOME.
Preferred term Geminin



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