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Descriptor English: Guanethidine
Descriptor Spanish: Guanetidina
Descriptor guanetidina
Scope note: Agente antihipertensor que actúa inhibiendo selectivamente la transmisión en los nervios adrenérgicos posganglionares. Se cree que actúa principalmente previniendo la liberación de norepinefrina en las terminaciones nerviosas y produce reducción de norepinefrina en las terminales nerviosas simpáticas periféricas y en los tejidos.
Descriptor Portuguese: Guanetidina
Descriptor French: Guanéthidine
Entry term(s): ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine
Guanethidine Monosulfate
Guanethidine Sulfate
Guanethidine Sulfate (1:1)
Guanethidine Sulfate (1:2)
Guanethidine Sulfate (2:1)
Guanethidine Sulfate (2:1), 14C-Labeled
Ismelin
Isobarin
Monosulfate, Guanethidine
Octadine
Oktadin
Sulfate, Guanethidine
Tree number(s): D02.078.370.460
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006145
Scope note: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antihypertensive Agents
Sympatholytics
Adrenergic Agents
Registry Number: ZTI6C33Q2Q
CAS Type 1 Name: Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-
DeCS ID: 6295
Unique ID: D006145
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Guanethidine - Preferred
Concept UI M0009675
Scope note An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Preferred term Guanethidine
Entry term(s) ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine
Octadine
Oktadin
Guanethidine Sulfate - Narrower
Concept UI M0350959
Preferred term Guanethidine Sulfate
Entry term(s) Guanethidine Sulfate (2:1)
Sulfate, Guanethidine
Guanethidine Sulfate (1:2) - Narrower
Concept UI M0330234
Preferred term Guanethidine Sulfate (1:2)
Ismelin - Narrower
Concept UI M0350958
Preferred term Ismelin
Isobarin - Narrower
Concept UI M0009676
Preferred term Isobarin
Guanethidine Monosulfate - Narrower
Concept UI M0330236
Preferred term Guanethidine Monosulfate
Entry term(s) Guanethidine Sulfate (1:1)
Monosulfate, Guanethidine
Guanethidine Sulfate (2:1), 14C-Labeled - Narrower
Concept UI M0330237
Preferred term Guanethidine Sulfate (2:1), 14C-Labeled



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