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Descriptor English:   Histocompatibility Antigens Class II 
Descriptor Spanish:   Antígenos de Histocompatibilidad Clase II 
Descriptor Portuguese:   Antígenos de Histocompatibilidade Classe II 
Synonyms English:   Antigen, Class II
Antigen, I-A
Antigen, IA
Antigens, Class II
Antigens, Ia
Antigens, Ia-Like
Antigens, Immune Response
Antigens, Immune-Associated
Antigens, Immune-Response-Associated
Class II Antigen
Class II Antigens
Class II Histocompatibility Antigens
Class II MHC Proteins
Class II Major Histocompatibility Antigens
Class II Major Histocompatibility Molecules
I A Antigen
I-A Antigen
IA Antigen
Ia Antigens
Ia Like Antigens
Ia-Like Antigens
Immune Associated Antigens
Immune Response Antigens
Immune Response Associated Antigens
Immune-Associated Antigens
Immune-Response-Associated Antigens
MHC Class II Molecules
MHC II Molecules
MHC II Peptides
MHC-II Molecules
Molecules, MHC-II
Peptides, MHC II  
Tree Number:   D12.776.395.550.509
Definition English:   Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen. 
Indexing Annotation English:   human & animal; see also HLA ANTIGENS & specifics for human
See Related English:   Genes, MHC Class II
History Note English:   1989 (1973); use ANTIGENS, IMMUNE RESPONSE 1981-88 
Allowable Qualifiers English:  
AD administration & dosage AN analysis
BI biosynthesis BL blood
CF cerebrospinal fluid CH chemistry
CL classification DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PD pharmacology PH physiology
PO poisoning RE radiation effects
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   24381 
Unique Identifier:   D000949 

Occurrence in VHL: