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Descriptor English: Isoprostanes
Descriptor Spanish: Isoprostanos
Descriptor isoprostanos
Scope note: Serie de compuestos similares a prostaglandinas, producidos por el acción de especies de radicales libres sobre los ácidos grasos insaturados, especialmente el ÁCIDO ARAQUIDÓNICO, de las MEMBRANAS celulares. Una vez escindidos de la membrana lipídica por la acción de fosfolipasas pueden circular en diversos líquidos orgánicos y, en último término, ser excretados. Aunque estos compuestos se asemejan a las prostaglandinas sintetizadas enzimáticamente, su disposición estereoisomérica suele ser diferente de la de los compuestos "naturales".
Descriptor Portuguese: Isoprostanos
Descriptor French: Isoprosane
Entry term(s): Isoprostane
Tree number(s): D10.251.355.255.100.375
D10.251.355.310.166.775
D10.251.355.411
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D028421
Scope note: A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Dinoprost (1992-2001)
Lipid Peroxides (1992-2001)
Public MeSH Note: 2002
History Note: 2002
DeCS ID: 36046
Unique ID: D028421
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/08/03
Revision Date: 2015/06/22
Isoprostanes - Preferred
Concept UI M0382190
Scope note A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.
Preferred term Isoprostanes
Entry term(s) Isoprostane



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