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Descriptor English: Katanin
Descriptor Spanish: Katanina
Descriptor katanina
Scope note: Enzima (ATPasa AAA) que consta de una subunidad ATPasa de 60 kDa (subunidad A1 de p60) que corta MICROTÚBULOS y de una proteína accesoria de 80kDa (subunidad B1 de p80) que dirige la enzima al CENTROSOMA. Esta enzima libera microtúbulos de los POLOS DEL HUSO MITÓTICO para permitir la despolimerización y el desplazamiento de los cromosomas hacia los polos. Además, es un regulador de la dinámica de los microtúbulos durante la PROYECCIÓN NEURONAL.
Descriptor Portuguese: Katanina
Descriptor French: Katanine
Tree number(s): D08.811.277.040.013.500.250
D08.811.277.040.025.024.250
D12.776.157.025.750.250
D12.776.220.600.450.325
D12.776.631.560.338
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074201
Scope note: An enzyme (AAA ATPase) consisting of the 60 kDa ATPase subunit (p60 subunit A1) which severs MICROTUBULES, and an 80 kDa accessory protein (p80 subunit B1), which targets the enzyme to the CENTROSOME. It releases microtubules from the mitotic SPINDLE POLES to allow depolymerization and poleward motion of chromosomes. It is also a regulator of microtubule dynamics in NEURONAL OUTGROWTH.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 5.6.1.1
Public MeSH Note: 2018; KATANIN was indexed under ADENOSINE TRIPHOSPHATASES 1993-2017
History Note: 2018 (1993)
Related: AAA Domain MeSH
DeCS ID: 56994
Unique ID: D000074201
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2019/07/08
Katanin - Preferred
Concept UI M000625785
Scope note An enzyme (AAA ATPase) consisting of the 60 kDa ATPase subunit (p60 subunit A1) which severs MICROTUBULES, and an 80 kDa accessory protein (p80 subunit B1), which targets the enzyme to the CENTROSOME. It releases microtubules from the mitotic SPINDLE POLES to allow depolymerization and poleward motion of chromosomes. It is also a regulator of microtubule dynamics in NEURONAL OUTGROWTH.
Preferred term Katanin



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