Search on: LISSENCEPHALY 
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Descriptor English:   Lissencephaly 
Descriptor Spanish:   Lisencefalia 
Descriptor Portuguese:   Lisencefalia 
Synonyms English:   Agyria
Agyrias
Broad Gyri of Cerebrum
Large Gyri of Cerebrum
Lissencephalia
Lissencephalies
Macrogyria
Macrogyrias
Pachygyria
Pachygyrias  
Tree Number:   C10.500.507.450.499
C16.131.666.507.450.499
Definition English:   A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex. 
Indexing Annotation English:   note specifics; MICROLISSENCEPHALY see MICROCEPHALY is also available
History Note English:   2008 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications DI diagnosis
DG diagnostic imaging DH diet therapy
DT drug therapy EC economics
EM embryology EN enzymology
EP epidemiology EH ethnology
ET etiology GE genetics
HI history IM immunology
ME metabolism MI microbiology
MO mortality NU nursing
PS parasitology PA pathology
PP physiopathology PC prevention & control
PX psychology RT radiotherapy
RH rehabilitation SU surgery
TH therapy UR urine
VE veterinary VI virology
Record Number:   52594 
Unique Identifier:   D054082 

Occurrence in VHL:
 
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