Search on: MEDIATOR COMPLEX 
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Descriptor English:   Mediator Complex 
Descriptor Spanish:   Complejo Mediador 
Descriptor Portuguese:   Complexo Mediador 
Synonyms English:   Mediator Like Complex
Mediator Like Complexes
Mediator Transcription Complex
Mediator-Like Complex
Mediator-Like Complexes
TR-Associated Protein (TRAP) Complex
TRAP (Thyroid Hormone Associated Protein) Complex
Thyroid Hormone Associated Protein Complex
Thyroid Hormone-Associated Protein Complex  
Tree Number:   D05.500.374
D12.644.360.024.309
D12.776.157.057.072
D12.776.476.024.388
D12.776.660.551
Definition English:   A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS. 
History Note English:   2010; for TRAP (THYROID HORMONE ASSOCIATED PROTEIN) COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX use MEDIATOR COMPLEX SUBUNIT 1 2003-2009 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   53573 
Unique Identifier:   D056892 

Occurrence in VHL:
 
LILACS    
MEDLINE    

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