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Descriptor English: Nogalamycin
Descriptor Spanish: Nogalamicina
Descriptor nogalamicina
Scope note: Antrociclina de una variedad del Streptomyces nogalater. Es un antineoplásico citolítico que inhibe la síntesis de ARN dependiente de ADN mediante unión al ADN.
Descriptor Portuguese: Nogalamicina
Descriptor French: Nogalamycine
Entry term(s): U 15167
U-15167
U15167
Tree number(s): D02.455.426.559.847.562.050.200.650
D04.615.562.050.200.650
D09.408.051.059.200.650
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009621
Scope note: An anthrocycline from a Streptomyces nogalater variant. It is a cytolytic antineoplastic that inhibits DNA-dependent RNA synthesis by binding to DNA.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antineoplastic
Intercalating Agents
Nucleic Acid Synthesis Inhibitors
Registry Number: L059DCD6IP
CAS Type 1 Name: 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha))-
Previous Indexing: Antibiotics (1966)
Antibiotics, Antineoplastic (1967-1975)
Glycosides (1966-1975)
Naphthacenes (1966-1975)
Public MeSH Note: 91; was see under DAUNORUBICIN 1981-90; was see under NAPHTHACENES 1976-80
History Note: 91(76); was see under DAUNORUBICIN 1981-90; was see under NAPHTHACENES 1976-80
DeCS ID: 24270
Unique ID: D009621
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1975/07/23
Revision Date: 2013/07/08
Nogalamycin - Preferred
Concept UI M0014939
Scope note An anthrocycline from a Streptomyces nogalater variant. It is a cytolytic antineoplastic that inhibits DNA-dependent RNA synthesis by binding to DNA.
Preferred term Nogalamycin
U-15167 - Narrower
Concept UI M0373561
Preferred term U-15167
Entry term(s) U 15167
U15167



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