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Descriptor English:   Oncogenes 
Descriptor Spanish:   Oncogenes 
Descriptor Portuguese:   Oncogenes 
Synonyms English:   Gene, Transforming
Genes, Transforming
Oncogene
Transforming Gene
Transforming Genes  
Tree Number:   G05.360.340.024.340.375.500
Definition English:   Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene. 
Indexing Annotation English:   "oncogene" used by author may refer to ONCOGENES or PROTO-ONCOGENES; do not confuse with ONCOGENS see CARCINOGENS; Manual 24.4.4.3; do not confuse with GENES, NEOPLASM
History Note English:   83 
Allowable Qualifiers English:  
DE drug effects ES ethics
GE genetics IM immunology
PH physiology RE radiation effects
Record Number:   10040 
Unique Identifier:   D009857 

Occurrence in VHL:
 
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