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Descriptor English: Osteocalcin
Descriptor Spanish: Osteocalcina
Descriptor osteocalcina
Entry term(s) proteína Gla ósea
proteína de unión al calcio dependiente de vitamina K
proteína ósea dependiente de vitamina K
Scope note: Proteína fijadora de calcio dependiente de la vitamina K sintetizada por los OSTEOBLASTOS que se encuentra principalmente en los HUESOS. Las determinaciones séricas de osteocalcina aportan un marcador específico no invasivo del metabolismo óseo. La proteína contiene tres residuos del aminoácido ácido gamma-carboxiglutámico (Gla), que, en presencia de CALCIO, promueve la fijación a la HIDROXIAPATITA y la posterior acumulación en la MATRIZ ÓSEA.
Descriptor Portuguese: Osteocalcina
Descriptor French: Ostéocalcine
Entry term(s): 4 Carboxyglutamic Protein, Bone
4-Carboxyglutamic Protein, Bone
Bone 4-Carboxyglutamic Protein
Bone Gla Protein
Bone gamma Carboxyglutamic Acid Protein
Bone gamma-Carboxyglutamic Acid Protein
Calcium Binding Protein, Vitamin K Dependent
Calcium-Binding Protein, Vitamin K-Dependent
Gla Protein, Bone
Protein, Bone 4-Carboxyglutamic
Protein, Bone Gla
Vitamin K Dependent Bone Protein
Vitamin K-Dependent Bone Protein
Tree number(s): D12.776.157.125.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015675
Scope note: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 104982-03-8
CAS Type 1 Name: Osteocalcin (human reduced), 3-de-L-tyrosine-4-de-L-glutamine-5-de-L-tryptophan-6-de-L-leucine-9-L-serine-12-L-serine-19-L-threonine-22-L-glutamine-28-L-alanine-33-L-serine-35-L-glutamine-36-L-tyrosine-38-L-leucine-39-L-lysine-40-L-threonine-43-L-lysine-45-L-isoleucine-48-L-isoleucine-49-L-threonine-49a-L-isoleucine-
Previous Indexing: 1-Carboxyglutamic Acid (1978-1981)
Binding Proteins (1978-1980)
Calcium (1978-1980)
Calcium-Binding Proteins (1980-1989)
Proteins (1980-1981)
Public MeSH Note: 90; GLA-PROTEIN was see OSTEOCALCIN 1990-96
Online Note: use OSTEOCALCIN to search GLA-PROTEIN 1990-96
History Note: 90; GLA-PROTEIN was see OSTEOCACLIN 1990-96
DeCS ID: 24820
Unique ID: D015675
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/09/06
Revision Date: 2004/07/07
Osteocalcin - Preferred
Concept UI M0024030
Scope note Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Preferred term Osteocalcin
Entry term(s) 4 Carboxyglutamic Protein, Bone
4-Carboxyglutamic Protein, Bone
Bone 4-Carboxyglutamic Protein
Bone Gla Protein
Bone gamma Carboxyglutamic Acid Protein
Bone gamma-Carboxyglutamic Acid Protein
Calcium Binding Protein, Vitamin K Dependent
Calcium-Binding Protein, Vitamin K-Dependent
Gla Protein, Bone
Protein, Bone 4-Carboxyglutamic
Protein, Bone Gla
Vitamin K Dependent Bone Protein
Vitamin K-Dependent Bone Protein



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