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Descriptor English: Osteopontin
Descriptor Spanish: Osteopontina
Descriptor osteopontina
Scope note: Proteína de la matriz extracelular cargada negativamente que desempeña un papel en la regulación del metabolismo del HUESO y en una variedad de otras funciones biológicas. Puede producirse la señalización celular por la osteopontina por medio de una secuencia de adhesión celular que reconoce la INTEGRINA ALFA-V BETA-3.
Descriptor Portuguese: Osteopontina
Descriptor French: Ostéopontine
Entry term(s): Bone Sialoprotein 1
Bone Sialoprotein I
Secreted Phosphoprotein 1
Sialoprotein 1
Sialoprotein 1, Bone
Sialoprotein I, Bone
Uropontin
Tree number(s): D12.644.276.374.625
D12.776.395.700.837
D12.776.467.374.625
D12.776.860.300.762
D23.529.374.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053495
Scope note: A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 106441-73-0
Public MeSH Note: 2007; OSTEOPONTIN was indexed under SIALOGLYCOPROTEINS 1987-2006
History Note: 2007(1987)
DeCS ID: 52284
Unique ID: D053495
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2010/06/25
Osteopontin - Preferred
Concept UI M0144031
Scope note A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Preferred term Osteopontin
Entry term(s) Bone Sialoprotein 1
Bone Sialoprotein I
Secreted Phosphoprotein 1
Sialoprotein 1
Sialoprotein 1, Bone
Sialoprotein I, Bone
Uropontin - Narrower
Concept UI M0195574
Scope note A urinary form of osteopontin.
Preferred term Uropontin



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