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Descriptor English: Papaverine
Descriptor Spanish: Papaverina
Descriptor papaverina
Scope note: Alcaloide que se encuentra en el opio pero que no se encuentra estrechamente relacionado con los demás alcaloides del opio en cuanto a su estructura o efectos farmacológicos. Es un relajante de acción directa de la musculatura lisa utilizado en el tratamiento de la impotencia y como vasodilatador, especialmente para la vasodilatación cerebral. El mecanismo de sus acciones farmacológicas no está claro, pero aparentemente puede inhibir las fosfodiesterasas y puede tener acciones directas sobre los canales de calcio.
Descriptor Portuguese: Papaverina
Descriptor French: Papavérine
Entry term(s): Cerespan
Hydrochloride, Papaverine
Papaverine Hydrochloride
Pavabid
Pavatym
Tree number(s): D03.132.098.666
D03.132.577.750
D03.633.100.531.085.666
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010208
Scope note: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Phosphodiesterase Inhibitors
Vasodilator Agents
Urological Agents
Registry Number: DAA13NKG2Q
CAS Type 1 Name: Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-
DeCS ID: 10395
Unique ID: D010208
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Papaverine - Preferred
Concept UI M0015830
Scope note An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Preferred term Papaverine
Pavatym - Narrower
Concept UI M0353767
Preferred term Pavatym
Pavabid - Narrower
Concept UI M0353766
Preferred term Pavabid
Cerespan - Narrower
Concept UI M0015831
Preferred term Cerespan
Papaverine Hydrochloride - Narrower
Concept UI M0331238
Preferred term Papaverine Hydrochloride
Entry term(s) Hydrochloride, Papaverine



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