Search on: PERFORIN 
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Descriptor English:   Perforin 
Descriptor Spanish:   Perforina 
Descriptor Portuguese:   Perforina 
Synonyms English:   Cytolysin
Lymphocyte Pore Forming Protein
Lymphocyte Pore-Forming Protein
Perforin 1
Pore-Forming Protein, Lymphocyte  
Tree Number:   D12.776.543.695.875
Definition English:   A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell. 
Pharmacological Action:   Cytotoxins
History Note English:   2008 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   52798 
Unique Identifier:   D054353 

Occurrence in VHL: