Search on: PHENYTOIN 
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Descriptor English:   Phenytoin 
Descriptor Spanish:   Fenitoína 
Descriptor Portuguese:   Fenitoína 
Synonyms English:   5,5-Diphenylhydantoin
5,5-diphenylimidazolidine-2,4-dione
Antisacer
Difenin
Dihydan
Dilantin
Epamin
Epanutin
Hydantol
Phenytoin Sodium
Sodium Diphenylhydantoinate
Diphenylhydantoinate, Sodium
Diphenylhydantoin
Fenitoin  
Tree Number:   D03.383.129.308.432.555.730
Definition English:   An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. 
Pharmacological Action:   Anticonvulsants
Cytochrome P-450 CYP1A2 Inducers
Voltage-Gated Sodium Channel Blockers
 
History Note English:   78; was DIPHENYLHYDANTOIN 1963-77 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   10867 
Unique Identifier:   D010672 

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