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Descriptor English: Polyadenylation
Descriptor Spanish: Poliadenilación
Descriptor poliadenilación
Scope note: Adición de un tramo de ácido poliadenílico (POLI A) en el extremo 3' de ARNm (ARN MENSAJERO). La poliadenilación requiere el reconocimiento de la señal del punto de proceso (AAUAAA), y la escisión del ARNm para crear un terminal OH en 3' al que la poli A (POLINUCLEOTIDO ADENILILTRANSFERASA) pueda unir 60-200 residuos de adenilato. El extremo 3' de algunos ARNs mensajeros, como la histona ARNm, se efectúa a través de diversos procesos que no incluyen la adición de poli A tal y como se describe aquí.
Descriptor Portuguese: Poliadenilação
Descriptor French: Polyadénylation
Entry term(s): Polyadenylations
Tree number(s): G02.111.760.225.710
G03.839.225.710
G05.308.700.225.710
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D026723
Scope note: The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Poly A/metabolism (1975-2001)
RNA, Messenger/metabolism (1974-2001)
Public MeSH Note: 2002
History Note: 2002
DeCS ID: 36334
Unique ID: D026723
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2016/06/23
Polyadenylation - Preferred
Concept UI M0378712
Scope note The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.
Preferred term Polyadenylation
Entry term(s) Polyadenylations



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