Search on: PYRANTEL 
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Descriptor English:   Pyrantel 
Descriptor Spanish:   Pirantel 
Descriptor Portuguese:   Pirantel 
Tree Number:   D02.886.778.634
D03.383.742.634
D03.383.903.634
Definition English:   A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920) 
Indexing Annotation English:   an antinematodal agent
Pharmacological Action:   Antinematodal Agents
Neuromuscular Depolarizing Agents
 
History Note English:   74 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   12151 
Unique Identifier:   D011715 

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