Search on: QUINIDINE 
Descriptors Found: 1
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Descriptor English:   Quinidine 
Descriptor Spanish:   Quinidina 
Descriptor Portuguese:   Quinidina 
Synonyms English:   Adaquin
Apo Quinidine
Apo-Quinidine
Chinidin
Quincardine
Quinidex
Quinidine Sulfate
Quinora
Sulfate, Quinidine  
Tree Number:   D03.132.206.636
D03.605.687.637
D03.633.100.810.699
Definition English:   An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. 
Pharmacological Action:   Adrenergic alpha-Antagonists
Anti-Arrhythmia Agents
Antimalarials
Enzyme Inhibitors
Muscarinic Antagonists
Voltage-Gated Sodium Channel Blockers
Cytochrome P-450 CYP2D6 Inhibitors
 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   12239 
Unique Identifier:   D011802 

Occurrence in VHL:
 
LILACS    
MEDLINE    
MedCarib    
IBECS    

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