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Descriptor English: Securin
Descriptor Spanish: Securina
Descriptor securina
Scope note: La securina está implicada en el control de la transición metafase-anafase durante la MITOSIS. Promueve el inicio de la anafase mediante el bloqueo de la función de la SEPARASA y previene la proteólisis de la cohesina y la separación de las CROMÁTIDES hermanas. La sobreexpresión de securina se asocia a TRANSFORMACIÓN CELULAR NEOPLÁSICA y formación de tumores.
Descriptor Portuguese: Securina
Descriptor French: Sécurine
Entry term(s): PTTG Protein
Pituitary Tumor Transforming Proteins
Pituitary Tumor-Transforming Gene Protein
Pituitary Tumor-Transforming Proteins
Tree number(s): D12.776.167.504
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064249
Scope note: Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Neoplasm Proteins (1997-2013)
Public MeSH Note: 2014; was indexed under NEOPLASM PROTEINS 1997-2013
History Note: 2014
DeCS ID: 55328
Unique ID: D064249
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Securin - Preferred
Concept UI M0580548
Scope note Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
Preferred term Securin
Entry term(s) PTTG Protein
Pituitary Tumor Transforming Proteins
Pituitary Tumor-Transforming Gene Protein
Pituitary Tumor-Transforming Proteins



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