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Descriptor English:   Small Leucine-Rich Proteoglycans 
Descriptor Spanish:   Proteoglicanos Pequeños Ricos en Leucina 
Descriptor Portuguese:   Proteoglicanos Pequenos Ricos em Leucina 
Synonyms English:   SLRP Proteoglycans
Small Leucine Rich Proteoglycans
Small Leucine Rich Repeat Proteoglycan
Small Leucine Rich Repeat Proteoglycans
Small Leucine-Rich Repeat Proteoglycan
Small Leucine-Rich Repeat Proteoglycans  
Tree Number:   D09.698.735.700
Definition English:   A proteoglycan family (SLRPs) that is defined by a central domain which consists of a variable number of repeats of the motif LXXLxLXXNxL, where L may be LEUCINE; ISOLEUCINE; VALINE; or other hydrophobic amino acids. The N-terminal contains four conserved CYSTEINE residues and may be modified depending on function. SLRPs provide structural support to the EXTRACELLULAR MATRIX and are critical for regulating its assembly and dynamics at CELL-MATRIX JUNCTIONS. 
History Note English:   2017 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56522 
Unique Identifier:   D000071232 

Occurrence in VHL: