Search on: SODIUM CHANNEL BLOCKERS 
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Descriptor English:   Sodium Channel Blockers 
Descriptor Spanish:   Bloqueadores de los Canales de Sodio 
Descriptor Portuguese:   Bloqueadores dos Canais de Sódio 
Synonyms English:   Channel Blockers, Sodium
Channel Inhibitors, Sodium
Inhibitors, Sodium Channel
Sodium Channel Inhibitors  
Tree Number:   D27.505.519.562.750
D27.505.954.411.720
Definition English:   A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity. 
Indexing Annotation English:   coordinate with DIURETICS if pertinent
See Related English:   Anti-Arrhythmia Agents
 
History Note English:   2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   36264 
Unique Identifier:   D026941 

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