Search on: SPHEROIDS, CELLULAR 
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Descriptor English:   Spheroids, Cellular 
Descriptor Spanish:   Esferoides Celulares 
Descriptor Portuguese:   Esferoides Celulares 
Synonyms English:   Cellular Spheroid
Cellular Spheroids
Multicellular Spheroid
Multicellular Spheroids
Spheroid, Cellular
Spheroid, Multicellular
Spheroids, Multicellular  
Tree Number:   A11.251.800
Definition English:   Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4) 
Indexing Annotation English:   do not confuse with "spheroid bodies" referring to axons in neuropathol; if tumor spheroids coordinate with TUMOR CELLS, CULTURED
History Note English:   2004(1996) 
Allowable Qualifiers English:  
CH chemistry CL classification
CY cytology DE drug effects
EN enzymology IM immunology
ME metabolism MI microbiology
PS parasitology PA pathology
PH physiology RE radiation effects
TR transplantation UL ultrastructure
VI virology  
Record Number:   32606 
Unique Identifier:   D018874 

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