Search on: SPIRONOLACTONE 
Descriptors Found: 1
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Descriptor English:   Spironolactone 
Descriptor Spanish:   Espironolactona 
Descriptor Portuguese:   Espironolactona 
Synonyms English:   Aldactone
Aldactone A
Aquareduct
Ct, Spiro Von
Duraspiron
Espironolactona Alter
Espironolactona Mundogen
Flumach
Frumikal
Jenaspiron
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Practon
SC 9420
SC-9420
SC9420
Spiractin
Spiro L.U.T.
Spiro Von Ct
Spirobeta
Spirogamma
Spirolactone
Spirolang
Spirono Isis
Spirono-Isis
Spironone
Spirospare
Veroshpiron
Verospiron
Verospirone
Von Ct, Spiro  
Tree Number:   D02.540.679
D04.210.500.745.745.855
Definition English:   A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827) 
Pharmacological Action:   Mineralocorticoid Receptor Antagonists
Diuretics
 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   13531 
Unique Identifier:   D013148 

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