Search on: TRANSFORMING GROWTH FACTOR BETA 
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Descriptor English:   Transforming Growth Factor beta 
Descriptor Spanish:   Factor de Crecimiento Transformador beta 
Descriptor Portuguese:   Fator de Crescimento Transformador beta 
Synonyms English:   Bone Derived Transforming Growth Factor
Bone-Derived Transforming Growth Factor
Factor, Milk Growth
Growth Factor, Milk
Milk Growth Factor
Platelet Transforming Growth Factor
TGF-beta
TGFbeta  
Tree Number:   D12.644.276.374.687
D12.644.276.954.775
D12.776.467.374.687
D12.776.467.942.775
D23.529.374.687
D23.529.942.775
Definition English:   A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. 
History Note English:   91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   29139 
Unique Identifier:   D016212 

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