Search on: TRIMETHOPRIM 
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Descriptor English:   Trimethoprim 
Descriptor Spanish:   Trimetoprim 
Descriptor Portuguese:   Trimetoprima 
Synonyms English:   Proloprim
Trimpex  
Tree Number:   D03.383.742.906
Definition English:   A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. 
Indexing Annotation English:   consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria
Pharmacological Action:   Anti-Infective Agents, Urinary
Antimalarials
Folic Acid Antagonists
Anti-Dyskinesia Agents
Cytochrome P-450 CYP2C8 Inhibitors
 
See Related English:   Trimethoprim Resistance
 
History Note English:   1974 (1972) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   14697 
Unique Identifier:   D014295 

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