Search on: UBIQUITIN-PROTEIN LIGASE COMPLEXES 
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Descriptor English:   Ubiquitin-Protein Ligase Complexes 
Descriptor Spanish:   Complejos de Ubiquitina-Proteína Ligasa 
Descriptor Portuguese:   Complexos Ubiquitina-Proteína Ligase 
Synonyms English:   Complexes, Ubiquitin-Protein Ligase
Ligase Complexes, Ubiquitin-Protein
Ubiquitin Protein Ligase Complexes  
Tree Number:   D08.811.464.938
Definition English:   Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES). 
Indexing Annotation English:   UBIQUITIN-PROTEIN LIGASES is also available
History Note English:   2004 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   38180 
Unique Identifier:   D043743 

Occurrence in VHL:
 
LILACS    
MEDLINE    
IBECS    

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