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Descriptor English:   Ubiquitin-Protein Ligases 
Descriptor Spanish:   Ubiquitina-Proteína Ligasas 
Descriptor Portuguese:   Ubiquitina-Proteína Ligases 
Synonyms English:   E3 Ligase
E3 Ubiquitin Ligase
Ligase E3, Ubiquitin
Ligase E3, Ubiquitin-Protein
Ligase, E3
Ligase, E3 Ubiquitin
Ligase, Ubiquitin-Protein
Ligases, Ubiquitin-Protein
Ubiquitin Ligase E3
Ubiquitin Ligase, E3
Ubiquitin Protein Ligase
Ubiquitin Protein Ligase E3
Ubiquitin Protein Ligases
Ubiquitin-Protein Ligase
Ubiquitin-Protein Ligase E3  
Tree Number:   D08.811.464.938.750
Definition English:   A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes. 
Indexing Annotation English:   UBIQUITIN-PROTEIN LIGASE COMPLEXES is also available
History Note English:   2004; use UBIQUITIN-PROTEIN LIGASE (NM) 1983-2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   38183 
Unique Identifier:   D044767 

Occurrence in VHL: