Search on: X-RAY REPAIR CROSS COMPLEMENTING PROTEIN 1 
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Descriptor English:   X-ray Repair Cross Complementing Protein 1 
Descriptor Spanish:   Proteína 1 de Reparación por Escisión del Grupo de Complementación Cruzada de las Lesiones por Rayos X 
Descriptor Portuguese:   Proteína 1 Complementadora Cruzada de Reparo de Raio-X 
Synonyms English:   X ray Repair Cross Complementing Protein 1
XRCC1 DNA Repair Protein
XRCC1 Protein  
Tree Number:   D12.776.157.687.813
D12.776.260.963
D12.776.660.720.813
Definition English:   A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS. 
History Note English:   2018 (1994) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   57099 
Unique Identifier:   D000076105 

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