Pesquisa sobre: ANISTREPLASE 
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Descritor Inglês:   Anistreplase 
Descritor Espanhol:   Anistreplasa 
Descritor Português:   Anistreplase 
Sinônimos Inglês:   APSAC
Anisoylated Plasminogen-Streptokinase Activator Complex
BRL 26921
Categoria:   D08.811.277.656.300.760.635.075
Definição Inglês:   An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents. 
Ação Farmacológica:   Fibrinolytic Agents
Nota Histórica Inglês:   91 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   28860 
Identificador Único:   D016255 

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