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Descriptor English: Apoptosomes
Descriptor Spanish: Apoptosomas
Descriptor apoptosomas
Scope note: Complejos proteicos multiméricos que se forman en el CITOSOL e intervienen en la activación de la APOPTOSIS. Pueden aparecer cuando se producen lesiones de las MITOCONDRIAS debidas a estrés celular con liberación de CITOCROMO C. El citocromo C citosólico se asocia al FACTOR 1 DE ACTIVACIÓN DE PROTEASAS APOPTÓSICAS para formar el complejo proteico apoptosómico. El apoptosoma señala la apoptosis uniéndose a CASPASAS INICIADORAS específicas, como la CASPASA 9, y activándolas.
Descriptor Portuguese: Apoptossomas
Descriptor French: Apoptosomes
Entry term(s): Apoptosomal Protein Complex
Apoptosome
Complex, Apoptosomal Protein
Protein Complex, Apoptosomal
Tree number(s): D05.500.099
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053478
Scope note: Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Apoptosis (1999-2006)
Public MeSH Note: 2007
History Note: 2007
DeCS ID: 52179
Unique ID: D053478
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Apoptosomes - Preferred
Concept UI M0493498
Scope note Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
Preferred term Apoptosomes
Entry term(s) Apoptosomal Protein Complex
Apoptosome
Complex, Apoptosomal Protein
Protein Complex, Apoptosomal



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