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Descriptor English: Benserazide
Descriptor Spanish: Benserazida
Descriptor benseracida
Entry term(s) Ro 4-4602
seracida
seriltrihidroxibencilhidracina
Scope note: Inhibidor de la DOPA DESCARBOXILASA que no penetra en el interior del sistema nervioso central. Se administra frecuentemente con LEVODOPA en el tratamiento del parkinsonismo para prevenir la conversión de levodopa a dopamina en la periferia, aumentando de este modo la cantidad que alcanza el sistema nervioso central y reduciendo la dosis requerida. No tiene acciones antiparkinsonianas cuando se administra solo.
Descriptor Portuguese: Benserazida
Descriptor French: Bensérazide
Entry term(s): Benzylhydrazine, Seryltrihydroxy
DL-Serine 2-((2,3,4-trihydroxyphenyl)methyl)hydrazide
Ro 4 4602
Ro 4-4602
Ro 44602
Serazide
Seryltrihydroxy Benzylhydrazine
Seryltrihydroxybenzylhydrazine
Tree number(s): D02.442.175
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001545
Scope note: An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antiparkinson Agents
Enzyme Inhibitors
Dopamine Agents
Registry Number: 762OS3ZEJU
CAS Type 1 Name: DL-Serine, 2-((2,3,4-trihydroxyphenyl)methyl)hydrazide
Previous Indexing: Benzene (1966-1967)
Benzene Derivatives (1968-1971)
Benzyl Compounds (1972)
Hydrazines (1966-1972)
Serine (1966-1972)
Public MeSH Note: 91; was see under HYDRAZINES 1979-90; was SERYLTRIHYDROXY BENZYLHYDRAZINE see under HYDRAZINES 1975-78
Online Note: use BENSERAZIDE to search SERYLTRIHYDROXY BENZYLHYDRAZINE 1973-78 (as Prov 73-74)
History Note: 91(79); was see under HYDRAZINES 1979-90; was SERYLTRIHYDROXY BENZYLHYDRAZINE see under HYDRAZINES 1973-78 (Prov 1973-74)
DeCS ID: 23953
Unique ID: D001545
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Benserazide - Preferred
Concept UI M0002315
Scope note An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.
Preferred term Benserazide
Entry term(s) Benzylhydrazine, Seryltrihydroxy
DL-Serine 2-((2,3,4-trihydroxyphenyl)methyl)hydrazide
Serazide
Seryltrihydroxy Benzylhydrazine
Seryltrihydroxybenzylhydrazine
Ro 4-4602 - Narrower
Concept UI M0002316
Preferred term Ro 4-4602
Entry term(s) Ro 4 4602
Ro 44602



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