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Descritor Inglês:   COP9 Signalosome Complex 
Descritor Espanhol:   Complejo del Señalosoma COP9 
Descritor Português:   Complexo do Signalossomo COP9 
Sinônimos Inglês:   COP9 Signalosome (CSN)
COP9 Signalosome Subunit 1
COP9 Signalosome Subunit 2
COP9 Signalosome Subunit 3
COP9 Signalosome Subunit 4
COP9 Signalosome Subunit 5
COP9 Signalosome Subunit 6
COP9 Signalosome Subunit 7A
COP9 Signalosome Subunit 7B
COP9 Signalosome Subunit 8
COP9 Signalsome
Constitutive Photomorphogenesis 9 Signalosome
Constitutive Photomorphogenesis 9 Signalsome
FUSCA Protein 11
G Protein Pathway Suppressor 1
Signalosome Complex, COP9
Signalosome Subunit 3
Signalsome, COP9
Subunit 3, Signalosome  
Categoria:   D05.500.139
Definição Inglês:   A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light. 
Nota Histórica Inglês:   2018 (1995); for COP9 SIGNALOSOME SUBUNIT 3 use SIGNALOSOME SUBUNIT 3 1998-2017 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   56980 
Identificador Único:   D000075686 

Ocorrência na BVS: