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Descriptor English: Caffeine
Descriptor Spanish: Cafeína
Descriptor cafeína
Scope note: Metilxantina de origen natural que se aporta a algunas bebidas y que también se usa como agente farmacológico. Los efectos farmacológicos más notables de la cafeína son la estimulación del sistema nervioso central, incrementando el estado de alerta y provocando agitación. También relaja el MÚSCULO LISO, estimula el MÚSCULO CARDÍACO y la DIURESIS, y parece que es útil para el tratamiento de determinados tipos de cefaleas. Se han observado diversas acciones celulares de la cafeína, aunque no están perfectamente determinados los perfiles farmacológicos de cómo contribuye a cada una de ellas. Entre los más importantes están la inhibición de las FOSFODIESTERASAS de nucleótidos cíclicos, el antagonismo de RECEPTORES DE ADENOSINA, y la modulación del calcio intracelular.
Descriptor Portuguese: Cafeína
Descriptor French: Caféine
Entry term(s): 1,3,7-Trimethylxanthine
Caffedrine
Coffeinum N
Coffeinum Purrum
Dexitac
Durvitan
No Doz
Percoffedrinol N
Percutaféine
Quick Pep
Quick-Pep
QuickPep
Vivarin
Tree number(s): D03.132.960.175
D03.633.100.759.758.824.175
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002110
Scope note: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Central Nervous System Stimulants
Phosphodiesterase Inhibitors
Purinergic P1 Receptor Antagonists
Registry Number: 3G6A5W338E
CAS Type 1 Name: 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
DeCS ID: 2143
Unique ID: D002110
NLM Classification: QV 107
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Caffeine - Preferred
Concept UI M0003138
Scope note A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Preferred term Caffeine
Entry term(s) 1,3,7-Trimethylxanthine
Vivarin - Narrower
Concept UI M0466584
Preferred term Vivarin
Caffedrine - Narrower
Concept UI M0466578
Preferred term Caffedrine
Coffeinum N - Narrower
Concept UI M0466579
Preferred term Coffeinum N
Percutaféine - Narrower
Concept UI M0466585
Preferred term Percutaféine
Dexitac - Narrower
Concept UI M0466581
Preferred term Dexitac
Durvitan - Narrower
Concept UI M0466582
Preferred term Durvitan
No Doz - Narrower
Concept UI M0003139
Preferred term No Doz
Percoffedrinol N - Narrower
Concept UI M0466583
Preferred term Percoffedrinol N
Quick-Pep - Narrower
Concept UI M0473599
Preferred term Quick-Pep
Entry term(s) Quick Pep
QuickPep
Coffeinum Purrum - Narrower
Concept UI M0466580
Preferred term Coffeinum Purrum



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