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Descriptor English: Calpain
Descriptor Spanish: Calpaína
Descriptor calpaína
Entry term(s) calpaína I
calpaína II
proteasa neutra activada por calcio
proteinasa neutra dependiente del calcio
Scope note: Cisteína proteinasa que se encuentra en muchos tejidos. Hidroliza diferentes proteínas endógenas, entre ellas los NEUROPÉPTIDOS, las PROTEÍNAS CITOESQUELÉTICAS, las proteínas del MÚSCULO LISO, del MÚSCULO CARDIACO, del hígado, de las plaquetas y de los eritrocitos. Se conocen dos subclases, con alta y baja sensibilidad al calcio. Elimina los discos Z y líneas N de las miofibrillas. Activa la fosforilasa quinasa y la proteinquinasa independiente de nucleótido cíclico. Esta enzima fue anteriormente listada como EC 3.4.22.4.
Descriptor Portuguese: Calpaína
Descriptor French: Calpain
Entry term(s): Ca2+ Activated Protease
Ca2+-Activated Protease
Calcium Activated Neutral Protease
Calcium Activated Neutral Proteinase
Calcium Activated Protease
Calcium Dependent Neutral Protease
Calcium Dependent Neutral Proteinase
Calcium-Activated Neutral Protease
Calcium-Activated Neutral Proteinase
Calcium-Activated Protease
Calcium-Dependent Neutral Protease
Calcium-Dependent Neutral Proteinase
Calpain I
Calpain II
Desminase
Neutral Protease, Calcium-Activated
Neutral Protease, Calcium-Dependent
Neutral Proteinase, Calcium-Activated
Neutral Proteinase, Calcium-Dependent
Protease, Ca2+-Activated
Protease, Calcium-Activated
Protease, Calcium-Activated Neutral
Protease, Calcium-Dependent Neutral
Proteinase, Calcium-Activated Neutral
Proteinase, Calcium-Dependent Neutral
Tree number(s): D08.811.277.656.262.500.120
D08.811.277.656.300.200.120
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002154
Scope note: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Annotation: /biosyn /physiol permitted
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.22.-
Previous Indexing: Peptide Peptidohydrolases (1966-1985)
Public MeSH Note: 86
History Note: 86
DeCS ID: 23227
Unique ID: D002154
NLM Classification: QU 136
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1985/04/25
Revision Date: 2016/06/28
Calpain - Preferred
Concept UI M0003226
Scope note Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Preferred term Calpain
Entry term(s) Ca2+ Activated Protease
Ca2+-Activated Protease
Calcium Activated Neutral Protease
Calcium Activated Neutral Proteinase
Calcium Activated Protease
Calcium Dependent Neutral Protease
Calcium Dependent Neutral Proteinase
Calcium-Activated Neutral Protease
Calcium-Activated Neutral Proteinase
Calcium-Activated Protease
Calcium-Dependent Neutral Protease
Calcium-Dependent Neutral Proteinase
Desminase
Neutral Protease, Calcium-Activated
Neutral Protease, Calcium-Dependent
Neutral Proteinase, Calcium-Activated
Neutral Proteinase, Calcium-Dependent
Protease, Ca2+-Activated
Protease, Calcium-Activated
Protease, Calcium-Activated Neutral
Protease, Calcium-Dependent Neutral
Proteinase, Calcium-Activated Neutral
Proteinase, Calcium-Dependent Neutral
Calpain II - Narrower
Concept UI M0003228
Preferred term Calpain II
Calpain I - Narrower
Concept UI M0003227
Preferred term Calpain I



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