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Descriptor English: Calreticulin
Descriptor Spanish: Calreticulina
Descriptor calreticulina
Scope note: Proteína multifuncional que se encuentra principalmente en los organelos unidos a membranas. En el RETÍCULO ENDOPLÁSMICO se une a oligosacáridos con unión N específica que se encuentran en las proteínas recientemente sintetizadas y funciona como CHAPERONA MOLECULAR que puede desempeñar un papel en el PLEGAMIENTO DE PROTEÍNAS o retención y degradación de proteínas mal plegadas. Además, la calreticulina es una forma de depósito principal para el CALCIO y funciona como molécula de señalización del calcio que puede regular la HOMEOSTASIS intracelular del calcio.
Descriptor Portuguese: Calreticulina
Descriptor French: Calréticuline
Entry term(s): 55 kDa High Affinity Calcium Binding Protein
55-kDa High-Affinity Calcium Binding Protein
CAB-63
CBP3 (Liver)
Calcium Binding Protein 3
Calcium-Binding Protein-3
Calregulin
ERp60
HACBP
cC1qR Protein
Tree number(s): D12.644.360.372.374
D12.776.157.125.412.374
D12.776.476.387.374
D12.776.503.303
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D037282
Scope note: A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Calcium-Binding Proteins (1990-2002)
Public MeSH Note: 2003; CALRETICULIN was indexed under CALCIUM-BINDING PROTEINS 1990-2002
History Note: 2003; use CALRETICULIN (NM) 1990-2002
DeCS ID: 37386
Unique ID: D037282
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2017/06/30
Calreticulin - Preferred
Concept UI M0172278
Scope note A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Preferred term Calreticulin
Entry term(s) 55 kDa High Affinity Calcium Binding Protein
55-kDa High-Affinity Calcium Binding Protein
CAB-63
CBP3 (Liver)
Calcium Binding Protein 3
Calcium-Binding Protein-3
Calregulin
ERp60
HACBP
cC1qR Protein



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