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Descritor Inglês:   Cardiac Glycosides 
Descritor Espanhol:   Glicósidos Cardíacos 
Descritor Português:   Glicosídeos Cardíacos 
Sinônimos Inglês:   Cardiotonic Steroids
Glycosides, Cardiac
Steroids, Cardiotonic  
Categoria:   D04.210.500.155.580
Definição Inglês:   Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose. 
Ação Farmacológica:   Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Número do Registro:   2345 
Identificador Único:   D002301 

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