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Descriptor English: Chalones
Descriptor Spanish: Chalonas
Descriptor chalonas
Scope note: Péptidos que inhiben la mitosis (ANTIMITÓTICOS). Durante los años sesenta, el término aludía a extractos no purificados que inhibían la proliferación celular; con posterioridad la actividad se atribuyó a oligopéptidos del tipo del PIROGLUTAMATO.
Descriptor Portuguese: Calônios
Descriptor French: Chalones
Tree number(s): D12.644.456.270
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050150
Scope note: Peptides that inhibit mitosis (ANTIMITOTICS). During the 1960's the term referred to crude extracts that inhibited cell proliferation; the activity was later attributed to PYROGLUTAMATE type oligopeptides.
Annotation: do not confuse with CHALCONES
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Growth Inhibitors (1993-2005)
Public MeSH Note: 2006, 1969-1992; see GROWTH INHIBITORS 1993-2005
History Note: 2006, 1969-1992; use GROWTH INHIBITORS 1993-2005
DeCS ID: 50818
Unique ID: D050150
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Chalones - Preferred
Concept UI M0009655
Scope note Peptides that inhibit mitosis (ANTIMITOTICS). During the 1960's the term referred to crude extracts that inhibited cell proliferation; the activity was later attributed to PYROGLUTAMATE type oligopeptides.
Preferred term Chalones



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