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Descriptor English: Cilastatin
Descriptor Spanish: Cilastatina
Descriptor cilastatina
Scope note: Inhibidor de la deshidropeptidasa-I renal y de la leucotrieno D4 dipeptidasa. Dado que el antibiótico, IMIPENEM, es hidrolizado por la deshidropeptidasa-I, que reside en el borde en cepillo del túbulo renal, se administra la cilastatina con imipenem para aumentar su eficacia. El fármaco inhibe también el metabolismo del leucotrieno D4 a leucotrieno E4.
Descriptor Portuguese: Cilastatina
Descriptor French: Cilastatine
Entry term(s): Cilastatin Monosodium Salt
Cilastatin Sodium
MK 0791
MK 791
MK-791
MK0791
MK791
Monosodium Salt, Cilastatin
Salt, Cilastatin Monosodium
Sodium, Cilastatin
Tree number(s): D02.455.426.392.368.533.200
D10.251.355.325.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015377
Scope note: A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Protease Inhibitors
Registry Number: 141A6AMN38
CAS Type 1 Name: 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-
Previous Indexing: Cyclopropanes (1983-1988)
Dipeptidases/antagonists & inhibitors (1983-1988)
Protease Inhibitors (1983-1988)
Public MeSH Note: 89
History Note: 89
DeCS ID: 23589
Unique ID: D015377
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/06/03
Revision Date: 2016/06/28
Cilastatin - Preferred
Concept UI M0023687
Scope note A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Preferred term Cilastatin
MK 0791 - Narrower
Concept UI M0351542
Preferred term MK 0791
Entry term(s) MK 791
MK-791
MK0791
MK791
Cilastatin Sodium - Narrower
Concept UI M0023688
Preferred term Cilastatin Sodium
Entry term(s) Cilastatin Monosodium Salt
Monosodium Salt, Cilastatin
Salt, Cilastatin Monosodium
Sodium, Cilastatin



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