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Descriptor English: Desipramine
Descriptor Spanish: Desipramina
Descriptor desipramina
Entry term(s) desmetilimipramina
Scope note: Dibenzacepina tricíclica que potencia la neurotransmisión. La desipramina bloquea selectivamente la recaptación de norepinefrina en los botones sinápticos, y también parece que dificulta el transporte de serotonina. Este compuesto posee, asimiismo, menor actividad anticolinérgica dada su afinidad por los receptores muscarínicos.
Descriptor Portuguese: Desipramina
Descriptor French: Désipramine
Entry term(s): Apo Desipramine
Apo-Desipramine
Demethylimipramine
Desipramine Hydrochloride
Desmethylimipramine
Hydrochloride, Desipramine
Norpramin
Novo Desipramine
Novo-Desipramine
Nu Desipramine
Nu-Desipramine
PMS Desipramine
PMS-Desipramine
Pertofran
Pertofrane
Pertrofran
Petylyl
Ratio Desipramine
Ratio-Desipramine
Tree number(s): D03.633.300.240.281
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003891
Scope note: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antidepressive Agents, Tricyclic
Enzyme Inhibitors
Adrenergic Uptake Inhibitors
Registry Number: TG537D343B
CAS Type 1 Name: 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-
Public MeSH Note: 65
History Note: 65(63)
DeCS ID: 3911
Unique ID: D003891
NLM Classification: QV 77.5
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Desipramine - Preferred
Concept UI M0006074
Scope note A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Preferred term Desipramine
Entry term(s) Demethylimipramine
Desmethylimipramine
Desipramine Hydrochloride - Narrower
Concept UI M0330514
Preferred term Desipramine Hydrochloride
Entry term(s) Hydrochloride, Desipramine
Norpramin - Narrower
Concept UI M0485024
Preferred term Norpramin
Ratio-Desipramine - Narrower
Concept UI M0485019
Preferred term Ratio-Desipramine
Entry term(s) Ratio Desipramine
Nu-Desipramine - Narrower
Concept UI M0485022
Preferred term Nu-Desipramine
Entry term(s) Nu Desipramine
Pertofrane - Narrower
Concept UI M0006075
Preferred term Pertofrane
Entry term(s) Pertofran
Pertrofran
Petylyl - Narrower
Concept UI M0485021
Preferred term Petylyl
PMS-Desipramine - Narrower
Concept UI M0485020
Preferred term PMS-Desipramine
Entry term(s) PMS Desipramine
Apo-Desipramine - Narrower
Concept UI M0485025
Preferred term Apo-Desipramine
Entry term(s) Apo Desipramine
Novo-Desipramine - Narrower
Concept UI M0485023
Preferred term Novo-Desipramine
Entry term(s) Novo Desipramine



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