| Descriptor English: | Disintegrins | ||||||
| Descriptor Spanish: |
Desintegrinas
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| Descriptor Portuguese: | Desintegrinas | ||||||
| Descriptor French: | Désintégrines | ||||||
| Entry term(s): |
Disintegrin |
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| Tree number(s): |
D12.644.138 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019483 | ||||||
| Scope note: | A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. |
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| Annotation: | polypeptides from snake venom; platelet aggregation inhib |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Pharm Action: |
Platelet Aggregation Inhibitors |
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| Previous Indexing: |
Peptides (1992-1996) Venoms (1992-1994) |
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| Public MeSH Note: | 97; DISINTEGRINS was indexed under PEPTIDES 1992-96 & VENOMS 1992-94 |
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| Online Note: | use DISINTEGRINS (NM) to search DISINTEGRINS 1992-96 |
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| History Note: | 97; was DISINTEGRINS (NM) 1992-96 |
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| DeCS ID: | 33035 | ||||||
| Unique ID: | D019483 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1997/01/01 | ||||||
| Date of Entry: | 1996/06/10 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Disintegrins
- Preferred
| Concept UI |
M0028974 |
| Scope note | A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. |
| Preferred term | Disintegrins |
| Entry term(s) |
Disintegrin |
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