Pesquisa sobre: ETOPOSIDE 
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Descritor Inglês:   Etoposide 
Descritor Espanhol:   Etopósido 
Descritor Português:   Etoposídeo 
Sinônimos Inglês:   Celltop
Demethyl Epipodophyllotoxin Ethylidine Glucoside
Eposide
Eposin
Eto GRY
Eto-GRY
Etomedac
Etopos
Etoposide Pierre Fabre
Etoposide Teva
Etoposide, (5S)-Isomer
Etoposide, (5a alpha)-Isomer
Etoposide, (5a alpha,9 alpha)-Isomer
Etoposide, alpha D Glucopyranosyl Isomer
Etoposide, alpha-D-Glucopyranosyl Isomer
Etoposido Ferrer Farma
Exitop
Lastet
NSC 141540
NSC-141540
NSC141540
Onkoposid
Riboposid
Teva, Etoposide
Toposar
VP 16
VP 16 213
VP 16-213
VP 16213
VP-16
VP16
Vepesid
Vépéside Sandoz
Vépéside-Sandoz
alpha-D-Glucopyranosyl Isomer Etoposide  
Categoria:   D02.455.426.559.847.638.960.675.250
D04.615.638.960.675.250
D09.408.348.275
Definição Inglês:   A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. 
Ação Farmacológica:   Antineoplastic Agents, Phytogenic
Topoisomerase II Inhibitors
 
Nota Histórica Inglês:   87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Número do Registro:   5143 
Identificador Único:   D005047 

Ocorrência na BVS:
 

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