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Descritor Inglês:   Fusion Proteins, bcr-abl 
Descritor Espanhol:   Proteínas de Fusión bcr-abl 
Descritor Português:   Proteínas de Fusão bcr-abl 
Sinônimos Inglês:   Bcr Abl Tyrosine Kinase
Bcr-Abl Tyrosine Kinase
Fusion Proteins, bcr abl
Kinase, Bcr-Abl Tyrosine
Oncogene Protein p185(bcr-abl)
Oncogene Protein p190(bcr-abl)
Oncogene Protein p210(bcr-abl)
Oncogene Protein p230(bcr-abl)
Tyrosine Kinase, Bcr-Abl
bcr abl Fusion Proteins
bcr-abl Fusion Proteins
p185(bcr-abl) Fusion Proteins
p190(bcr-abl) Fusion Proteins
p210(bcr-abl) Fusion Proteins
p230(bcr-abl) Fusion Proteins  
Categoria:   D08.811.913.696.620.682.725.500.500
Definição Inglês:   Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC. 
Relacionados Inglês:   Philadelphia Chromosome
Nota Histórica Inglês:   91; was BCR-ABL FUSION PROTEINS 1990 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   29237 
Identificador Único:   D016044 

Ocorrência na BVS: